DNA Damage Response and Repair Pathways Link Genomic Stability to Cancer Therapy

Help Center less All Topics Biology Molecular Biology DNA damage response DNA damage response description 2,477 papers group 21 followers add Follow lightbulb About this topic DNA damage response (DDR) refers to the complex network of cellular processes that detect, signal, and repair DNA lesions to maintain genomic stability.

It involves various proteins and pathways that coordinate cell cycle regulation, DNA repair mechanisms, and apoptosis in response to DNA damage caused by environmental factors or cellular metabolism.

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How do different DNA damage types and repair pathways interplay to maintain genomic stability and influence cancer therapeutics?

It addresses how the fidelity, timing, and choice of repair pathways influence mutagenesis, genomic instability, and therapeutic strategies that exploit DNA repair deficiencies.

The current state of eukaryotic DNA base damage and repair by Anita Corbett 2023, Nucleic acids research Key finding: This review details the biochemical mechanisms of classical base excision repair (BER) in eukaryotes, emphasizing the repair of oxidative and deamination-induced base lesions and their prevention from generating more…

It explores how such clustered lesions differ from isolated damage in repair difficulty, mutation risk, and contribution to genomic instability, carcinogenesis, and therapy resistance.

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Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis by Emmy Rogakou 2021, Cancers Key finding: This review defines clustered DNA damage as spatially proximal lesions including multiple strand breaks and base modifications induced by ionizing radiation (IR), which are more resistant to repair than isolated lesions.

How does the crosstalk between DNA damage response (DDR) and the immune system influence cellular outcomes and cancer therapy?

This theme focuses on the interplay between the cellular DNA damage response and immune signaling pathways, including innate and adaptive immunity.

It explores mechanisms by which DNA damage activates immune sensors such as cGAS-STING via micronuclei formation and cytoplasmic DNA, the role of DDR factors in modulating immune responses to infection, inflammation, and cancer, and the therapeutic implications of this interaction in enhancing cancer immunotherapy and mitigating immunological diseases.